Chapter 1661 Big Discovery! (Fifth More)

indeed!

Qi Kai and Yang Lan had question marks in their eyes along the way.

I don't know why Chen Cang thinks this old fox is a good person!

Doesn't he look like a good person?

After Chen Cang came back, he said to the two of them: "Let's go, go back to the laboratory first, I have something to say!"

Qi Kai and Yang Lan nodded immediately when they heard the sound, although they didn't know what was going on, but... they still walked over.

Chen Cang now the system has given several solutions!

All need to try.

However, his ability alone is limited now, and two people must cooperate to operate together.

Fortunately, both of them are veterans with rich experience, so all the experiments were done very quickly!

On the night that Thedanis left.

Chen Cang started to separate according to the system prompts.

He found that Lewy bodies, as intermediate products, should be present in body fluid markers!

However, according to a special detection method, he found that they were not completely similar!

If so...

Chen Cang suddenly said to Yang Lan and Qi Kai: "Actually... Lewy bodies are not a substance!"

"He should contain multiple substances, we should look for common ground in cerebrospinal fluid, urine, saliva!"

As soon as these words came out, the two immediately felt that it was feasible, and continued to frantically extract and research.

Now Chen Cang feels more and more that 5 days is too short!

But, on the fourth day!

The components of Lewy bodies were successfully deciphered: neurofilaments, tubulin, eosinophilic inclusion bodies composed of ubiquitin, and a special substance!

The discovery of this special substance made Chen Cang excited!

Because he found that this is a soluble protein expressed in the presynaptic and perinuclear areas of the central nervous system, which is closely related to the pathogenesis and related dysfunction of Parkinson's disease.

This great discovery directly made everyone in the office ecstatic!

It's almost a landmark victory!

After the discovery of this special substance.

Chen Cang continued to start testing according to the system's auxiliary methods.

One specific potential biomarker protein after another was discovered!

The most important one is one, which is a special symbol of information passed between neurotransmitters.

Everyone discovered that this turned out to be α-synuclein!

The discovery of α-synuclein brought the experiment to a new stage.

Because, through the inspection of body fluid markers, this substance was found in cerebrospinal fluid, saliva, and urine!

However, Chen Cang and others discovered during their research.

The reduction of saliva secretion in Parkinson's rats seems to be related to the damage of α-synuclein and the innervation of salivary gland autonomic nerves!

Then!

Chen Cang immediately began to study Parkinson's patients with a single symptom, and found that this α-synuclein was not simply a positive correlation!

For a while, it seems that the research on α-synuclein has fallen into a bottleneck period again!

On the same day, Chen Cang discovered that the rats were no longer able to provide research for their experiments, so they contacted Wu Hui and sent the patient's blood directly!

Then, Chen Cang connected the words of Triedanis!

Perhaps Parkinson's is not a degenerative disease.

After thinking of this possibility, Chen Cang suddenly realized.

This Tedanis is a complete liar.

Tedanis clearly wanted to bypass himself.

Because, after checking the results, Chen Cang found:

Parkinson's disease is a neurodegenerative disease, but it is not a simple degenerative disease. A key feature of this disease is the accumulation of damaged alpha-synuclein in Parkinson's patients.

So how exactly is damaged alpha-synuclein produced?

The tedious and boring scientific research made Chen Cang close to collapse!

During this period of time, in order not to waste every minute and every second, Chen Cang basically had very little rest time every day.

Rely on the use of potions to resist hard!

After this scene was seen by Yang Lan and Qi Kai, they couldn't help admiring it.

Perhaps Chen Cang's success was not accidental!

With such hard work, coupled with excellent personal ability and talent, it is impossible not to achieve results!

Just when Chen Cang's experiment reached a deadlock.

Chen Cang suddenly had an idea, and began to consult books to conduct research on α-synuclein itself!

This study actually had some different effects.

That is, in general, alpha-synuclein is a normal substance.

But why do T cells increase in the body?

What activated him?

Thinking of this, Chen Cang's mind started to run crazily.

Alpha-synuclein!

Parkinson!

T cells!

immune response!

...

All kinds of information kept mixing in my mind.

again and again!

Chen Cang began to speculate that it is impossible for normal α-synuclein to cause an immune response in the human body?

Could it be...

Is Parkinson's actually an immune response?

In this way, the immune response generated by the accumulation of alpha-synuclein is like an autoimmune response?

Thinking of this, Chen Cang suddenly felt that this is terrible!

Next, he began to quickly look up the information!

Then, through experiments, normal rats were injected with a large amount of extracted α-synuclein.

But……

no response!

The signaling factor did not elicit a neurological response in the rats.

T cells are normal!

Moreover, there was no Parkinson's reaction!

Why?

At this time, the system is now in the last few hours.

Chen Cang suddenly discovered a special substance.

This substance is strikingly similar to alpha-synuclein.

But not alpha-synuclein!

Chen Cang hurriedly asked Yang Lan to come over to help and conduct research!

this study.

Everyone was stunned!

Yang Lan said with some surprise: "Professor Chen, I said...you might discover a miracle!"

Chen Cang was taken aback for a moment: "What's going on?"

Qi Kai also stared wide-eyed, full of curiosity and anticipation!

Yang Lan wrote down the chemical equation of the item.

"This is a damaged α-synuclein that can become folded α-synuclein!"

"This kind of thing is likely to be the kind of item you mentioned that can induce a cellular immune response!"

When Chen Cang heard it, his eyes lit up!

He thought of all kinds of information, and suddenly said:

"Yes! Under normal circumstances, neurons are capable of clearing these abnormal α-synuclein!"

"However, the autoimmune response in Parkinson's disease arises when neurons are no longer able to clear abnormal alpha-synuclein."

"So, α-synuclein in Lewy bodies is probably a broken α-synuclein!"

At this time, Chen Cang suddenly recalled the words of Triedanis!

He smiled slightly: "Now you know that Professor Tidanes is not a bad guy, right?"

Qi Kai and Yang Lan were taken aback for a moment.

Chen Cang said slowly: "It's just as Triedanis said!"

"Parkinson's disease is partly an autoimmune disease!"

"And it is this folded alpha-synuclein that induces this immune disease!"

Chen Cang didn't say a word: That is...Tedanis may not know that Parkinson's is an autoimmune disease!

Otherwise, he would not have told himself the news.

...

...

ps: It was delivered at five o'clock, a little late, thank you for your support.