Chapter 1614 I Said I Would, Do You Believe It? (Fifth More)
Qi Kai never seriously considered Chen Cang's words before!
If other laymen ask, they may even find it childish and ridiculous.
Because doesn't a disease have these various comprehensive manifestations?
but!
Today is different!
Who is Chen Cang? This is a new star in the field of neurosurgery, and he is the pillar of the future of Chinese medicine!
Otherwise, would Xiao Runfang pay such a high price?
What is called regardless of cost and full cooperation!
When Qi Kai heard Chen Cang's words, he began to think back and ponder!
Resting tremor, muscle rigidity, bradykinesia... Can they be modeled separately?
What is the point of separation?
Thinking of this, Qi Kai looked at Chen Cang, and asked curiously: "Professor Chen, do you think it is meaningful to make models separately?"
Chen Cang nodded!
He is a person who has tens of millions of clinical experiences in human Parkinson's surgery.
He clearly remembered that the production of Parkinson's damaged stoves was definitely not just a single place.
It is necessary to select different areas to build lesion foci.
It is also the target selection for Parkinson's.
The ventrolateral nucleus of the thalamus is effective for tremor and stiffness, but not sure for bradykinesia.
The medial part of the globus pallidus is effective for stiffness and slowness of movement, followed by tremor!
And similarly, both are ventral intermediate nucleus of the thalamus, and the specific location of the lesion that Chen Cang needs surgery to make is also different!
Hearing Qi Kai's words, Chen Cang nodded and said, "Well, there is a difference!"
"When I was operating on a patient, Director Zhou Hongguang himself had Parkinson's symptoms of resting tremor in both hands. I chose the ventral intermediate nucleus of the thalamus, and the effect of the operation was obvious!"
"So, I guess, can some rat models be established in a targeted manner?"
Hearing Chen Cang's words, Qi Kai suddenly became enlightened: "Professor Chen's idea is very constructive!"
"Let's go, my studio is in front of me, let's come in and have a look!"
Chen Cang nodded, a little excited and looking forward to it.
...
...
After Qi Kai put on his clothes, he said to Chen Cang: "Our modeling process is actually based on medical knowledge!",
"It is mainly based on pathological features: loss of dopaminergic neurons in the substantia nigra, and appearance of Lewy bodies, intracytoplasmic inclusions."
"Under these combined effects, the occurrence of Parkinson's is actually a result: the balance between acetylcholine and dopamine is out of balance, acetylcholine increases and dopamine decreases."
Chen Cang nodded.
Chen Cang understood this pathological state.
The current main treatment options are dopamine drugs, or inhibit the secretion of acetylcholine to form a new balance.
but……
The effect is worrying!
Qi Kai introduced in detail while operating.
"Actually, this instrument is mainly for measuring dopamine."
"The number and shape of dopaminergic neurons are normal at birth, and they gradually decrease selectively during adolescence. When the decrease reaches 50%, various reactions can appear, and, through neurochemical and Neurophysiological methods detect this value, and you see... this is it!"
"This model can show the formation of Lewy bodies."
"By the way, this, we can detect heredity!"
"This thing is our unique skill, gringo, even the United States doesn't have such a skill!"
...
When introducing the instruments and results, Qi Kai was very excited and proud!
This is his lifelong pursuit.
When making models, Qi Kai was very serious.
The students on the side will help him again.
What Qi Kai did was not very strenuous.
The little mouse has been anesthetized and is lying on it to be slaughtered. He should be very happy to think that as long as he sleeps, he will be a noble Parkinson rat in the morning.
After all, his worth has multiplied by hundreds of times!
Pity.
It's not something it can decide on its own.
Qi Kai said: "Now we mainly use hexahydroxy-dopamine injection in the substantia nigra or medial forebrain bundle of rats!"
"It's a classic preparation!"
While speaking, the operation started.
Afterwards, he continued: "There is another method that has been developed in recent years, called MPTP tube feeding."
In the afternoon, Chen Cang witnessed several modeling methods!
Director Qi Kai is very knowledgeable!
He told Chen Cang a lot about the structure, physiology and pathology of rats.
It can be said that it has benefited a lot!
Just when Chen Cang was about to leave, Chen Cang suddenly discovered pleasantly:
My own progress bar has increased by 1 point!
Although only 1 point.
But this was enough to surprise Chen Cang.
[Parkinson's progress bar: 28%! 】
With the harvest, Chen Cang was naturally very pleasantly surprised!
The next day, Chen Cang continued to come!
Again, add 1 point!
For a few days in a row, Chen Cang was able to make simple models by himself!
Chen Cang's butcher's knife finally reaches the rat!
At this moment, the rat fell peacefully.
but……
Accompanied by a crisp reminder sound.
Chen Cang was pleasantly surprised to find out.
My own 30 progress bar has been reached!
【Ding! Congratulations, the Parkinson's progress bar has reached 30%, and you will be rewarded: Stereotaxic precise injection modeling method! 】
Accompanied by a warning sound.
Chen Cang was stunned!
Make... make... model! ?
me he...
What I want to obtain is not this thing at all.
Chen Cang wanted to cry but had no tears.
I want to save people.
Not a mouse!
but……
When Chen Cang finished reading this technique completely, Chen Cang was stunned!
This is not only a precise way of modeling animals.
It is also a treatment method for the human body!
This is a means of performing both internal and surgical procedures.
For modeling, stereotaxic injection of MPTP (a complex compound, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) into the intracranial approach.
After Chen Cang learned about it, he was pleasantly surprised.
Maybe... this can not only model animals, but also humans? !
As usual, Chen Cang turned to Director Qi and asked curiously: "Director Qi, what will happen if a simple rat model such as resting tremor, simple muscle rigidity, or simple balance disorder is developed? ?”
Qi Kai couldn't help laughing and said, "This...is amazing!"
"This is the core technology!"
"If that kind of technology is realized, our research on Parkinson's will be upgraded to a new level!"
"It will even directly speed up Parkinson's research!"
"This is a historic project. After you said it the other day, I went back and studied it. It's...not impossible, but...it's too difficult!"
Chen Cang smiled slightly: "Director Qi, look at my mice, they may all be in resting tremors, do you believe it?"
...
ps: Thanks to the 10,000 reward from the leader of Guoguo, thank you!
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